Press Release

Scilex Holding Company Announces that its Majority Stockholder, Sorrento Therapeutics, Inc., has Issued a Supplement to its Previously Issued “FAQ” Regarding the Dividend of Scilex Holding Company Common Stock

Scilex Holding Company (Nasdaq: SCLX) announced that its majority stockholder, Sorrento Therapeutics, Inc. (Nasdaq: SRNE, “Sorrento”) today posted a supplement to its previously issued “Frequently Asked Questions” document under the

“Investors” section of its website at www.sorrentotherapeutics.com regarding its recent dividend to Sorrento stockholders of shares of common stock of Scilex Holding Company held by Sorrento.

The supplement to the FAQs provides notice regarding the Depository Trust and Clearing Corporation’s removal of the contra-CUSIP on Scilex common stock that was distributed as a dividend to Sorrento’s stockholders and provides notice to brokerage firms, banks, dealers and similar organizations listed therein that a dividend confirmation had previously been distributed to such firms by Scilex’s transfer

agent and requests that such firms contact Scilex’s transfer agent if they have not received such confirmation. The supplement also reiterates a question related to issues that may arise with respect to the dividend in connection with short positions in Sorrento common stock.

The supplement to the FAQs and related annex are included in this press release and can also be found Scilex’s website https://www.scilexholding.com/investors/faqs/

SUPPLEMENT TO FREQUENTLY ASKED QUESTIONS

REGARDING THE DIVIDEND OF SCILEX HOLDING COMPANY COMMON STOCK BY SORRENTO THERAPEUTICS, INC.

This supplement is a supplement to the Frequently Asked Questions Regarding the Dividend of Scilex Holding Company Common Stock by Sorrento Therapeutics, Inc. (Sorrento) that was issued by Sorrento on January 29, 2023 (the FAQ), a copy of which can be found under the “Investors” section of its website at www.sorrentotherapeutics.com.

This supplement is being issued to update and supplement the information in the FAQ to notify investors regarding certain matters relating to the dividend and reiterate certain questions and answers from the FAQ. Capitalized terms used in this supplement shall have their respective meetings set forth in the FAQ.

NOTICE OF REMOVAL OF CONTRA-CUSIP BY DTCC

Effective as of February 2, 2023, the Depository Trust and Clearing Corporation has removed the “contra-CUSIP” that it had previously imposed on the Dividend Stock. Any shares of Dividend Stock held by your brokerage firm, bank, dealer or other similar organization for your benefit now bear only Scilex’s CUSIP number, which is 80880W106. If you are entitled to receive Dividend Stock,

please contact your brokerage firm, bank, or other similar organization immediately to confirm that the CUSIP number appears on your brokerage statement with respect to your Dividend Stock.

NOTICE TO BROKERAGE FIRMS, BANKS, DEALERS AND OTHER SIMILAR ORGANIZATIONS

If the name of your firm, bank or other similar organization is set forth on Annex B of the FAQ, which Annex B is repeated below for convenience, and your firm, bank or similar organization has not received the Dividend Confirmation that was mailed to your firm, bank or similar organization, please contact Scilex’s transfer agent immediately to obtain a copy of the Dividend Confirmation. Scilex’s transfer agent’s contact information is as follows:

Continental Stock Transfer & Trust Company Telephone Number: 800-509-5586

Email Address: cstmail@continentalstock.com

Several major brokers have confirmed to Sorrento and Scilex that they are adding the Scilex share positions to the individual brokerage accounts of Sorrento shareholders receiving the Dividend Stock

SUPPLEMENTAL QUESTION AND ANSWER

Q:If I loaned my shares of Sorrento common stock to short sellers or any other party as of the Record Date, am I still entitled to receive Dividend Stock as of the Payment Date?
A:Only Record Holders as of the Record Date are entitled to receive the Dividend Stock. If you were the Record Holder as of the Record Date and are entitled to receive the Dividend Stock, but have not received the Dividend Stock, you may be entitled to receive Dividend Stock from the short seller or other party who borrowed your shares of Sorrento common stock, whether through the lending programs implemented by your brokerage firm, bank, dealer and other similar organization or otherwise. If you were a Record Holder as of the Record Date and have not received your Dividend Stock, please consult with your financial advisor, broker or other agent immediately to determine how to receive your Dividend Stock.

Annex B Broker List

Broker NameBroker Address Broker Name
ABN AMRO CLEARING CHICAGO LLC175 WEST JACKSON BLVD. CHICAGOAlbert Fried & Company LLC45 BROADWAY, 24TH FLOOR 24TH FLOOR
Broker NameBroker Address Broker Name
 IL ILLINOIS 60604 US NEW YORK NY NEW YORK 10006 US
AMALGAMATED BANK275 7TH AVENUE NEW YORK NY NEW YORK 10003 USAMERICAN ENTERPRISE INVESTMENT SERVICES INC.682 AMERIPRISE FINANCIAL CENTER MINNEAPOLIS MN MINNESOTA 55474 US
APEX CLEARING CORPORATION2 GATEWAY CENTER 283-299 MARKET ST 16TH FLOOR NEWARK NJ NEW JERSEY 07102-5005 USBANK OF AMERICA, NA/GWIM TRUST OPERATIONS901 MAIN STREET 12TH FLOOR DALLAS TX TEXAS 23113 US
BANK OF NEW YORK MELLON111 SANDERS CREEK PARKWAY 2ND FLOOR 2ND FLOOR EAST SYRACUSE NY NEW YORK 13057 US.BARCLAYS CAPITAL INC.DTC CUSTODY PARTICIPANT- NY WINDOW -570 WASHINGTON BLVD (ATTN: ROSA HICKS- MILLER OR ROBERT MENDEZ JERSEY CITY NJ NEW JERSEY 07310 US
BARCLAYS CAPITAL INC.DTC CUSTODY PARTICIPANT- NY WINDOW -570 WASHINGTON BLVD (ATTN: ROSA HICKS-MILLER OR ROBERT MENDEZ JERSEY CITY NJ NEW JERSEY 07310 USBMO CAPITAL MARKETS CORP.3 2ND STREET 12TH FLOOR JERSEY CITY NJ NEW JERSEY 07302 US
BMO HARRIS BANK NA/TRUST11270 W PARK PL MILWAUKEE WI WISCONSIN 53224 USBMO Nesbitt Burns Inc., Toronto250 YONGE STREET, 7TH FLOOR 7TH FLOOR TORONTO ON ONTARIO M5B 2M8 CA CANADA
Broker NameBroker Address Broker Name
BNP PARIBAS, NEW YORK BRANCH/BNP PARIBAS PRIME BROKERAGE CUSTODIAN100 WEST 33RD STREET 3RD FLOOR NEW YORK NY NEW YORK 10001BNP PARIBAS, NEW YORK BRANCH/BNP PARIBAS PRIME BROKERAGE CUSTODIAN100 WEST 33RD STREET 3RD FLOOR NEW YORK NY NEW YORK 10001
BNY MELLONPO BOX 392002 500 ROSS STREET PITTSBURGH PA PENNSYLVANIA 15262 USBNY MELLON/WEALTH MANAGEMENT1 FREEDOM VALLEY DRIVE OAKS PA PENNSYLVANIA 19456 US
BNYMELLON111 SANDERS CREEK PARKWAY 2ND FLOOR 2ND FLOOR EAST SYRACUSE NY NEW YORK 13057 USBNYMELLON/RE BARCLAYS CAPITAL SECURITIES LTD.ONE WALL STREET NEW YORK NY NEW YORK 10286
BNYMELLON/RE CACEIS BANK LUXEMBOURG500 Grant St. BNY Mellon Center PITTSBURGH PA PENNSYLVANIA 15258BNYMELLON/RE CACEIS BANK, NETHERLANDS111 SANDERS CREEK PARKWAY EAST SYRACUSE NY NEW YORK 13057
BNYMELLON/RE CHARLES STANLEY AND COMPANY, LIMITED111 SANDERS CREEK PARKWAY 2ND FLOOR 2ND FLOOR EAST SYRACUSE NY NEW YORK 13057 USBNYMELLON/RE ETF – ISHARES DTC/NSCC111 SANDERS CREEK PARKWAY EAST SYRACUSE NY NEW YORK 13057
BNYMELLON/RE WINTERFLOOD SECURITIES LTD500 Grant St. BNY Mellon Center PITTSBURGH PA PENNSYLVANIA 15258BOFA4804 Deer Lake Drive East FL9-803-04-04- 4th floor JACKSONVILLE FL FLORIDA 32246 US
BOFA4804 Deer Lake Drive East FL9-803-04-04- 4th floor JACKSONVILLE FL FLORIDA 32246 USBOFA SECURITIES INC4804 Deer Lake Drive East FL9-803-04-04- 4th floor JACKSONVILLE FL FLORIDA 32246 US
Broker NameBroker Address Broker Name
BROWN BROTHERS HARRIMAN & CO.140 BROADWAY ATTN: CORPORATE ACTIONS VAULT NEW YORK NY NEW YORK 10005 USBROWN BROTHERS HARRIMAN & CO./ETF140 BROADWAY NEW YORK NY NEW YORK 10005
CALDWELL SECURITIES LTD./CDS**55 UNIVERSITY AVENUE SUITE 340 TORONTO ON ONTARIO M5J 2H7 CANADACANACCORD GENUITY CORP.609 GRANVILLE ST VANCOUVER BC BRITISH COLUMBIA V7Y 1H2 CA CANADA
CANTOR, FITZGERALD & CO.135 E 57TH ST 5TH FL NEW YORK NY NEW YORK 10041 USCDS CLEARING AND DEPOSITORY SERVICES INC.100 ADELAIDE STREET WEST TORONTO ON ONTARIO M5H 1S3 CA CANADA
CETERA INVESTMENT SERVICES LLC400 FIRST STREET SOUTH, SUITE 300 SUITE 300 ST. CLOUD MN MINNESOTA 56302-0283 USCHARLES SCHWAB & CO., INC.211 MAIN STREET SAN FRANCISCO CA CALIFORNIA 94105 US
CI INVESTMENT SERVICES INC.199 BAY STREET SUITE 2600 TORONTO ON ONTARIO M5L 1E2 CA CANADACIBC WORLD MARKETS INC./CDS**161 BAY STREET 10 FL TORONTO ON ONTARIO M5J 2S8 CA CANADA
CITIBANK, N.A./ETF3800 CITIGROUP CENTER B2/2 TAMPA FL FLORIDA 33610CITIBANK, NATIONAL ASSOCIATION3800 CITIBANK CENTER TAMPA BLDG.B FIRST FLOOR ZONE 8 TAMPA FL FLORIDA 33610-9122 US
CITIGROUP GLOBAL MARKETS, INC.580 CROSSPOINT PARKWAY GETZVILLE NY NEW YORK 14068 USCLEAR STREET LLC4 World Trade Center, 45th Floor 150 Greenwich Street NEW YORK NY NEW YORK 10007
CLEARSTREET IO55 BROADWAY (SUITE 2102) CORPORATE ACTIONSCOMMERCE BANK922 WALNUT STREET MAIL STOP TBTS-2 KANSAS CITY
Broker NameBroker Address Broker Name
 NEW YORK NEW YORK 10006 US MO MISSOURI 64106 US
COR CLEARING LLC9300 UNDERWOOD AVE SUITE 400 OMAHA NE NEBRASKA 68114 USCredential Securities Inc.800-1111 WEST GEORGIA STREET VANCOUVER BC BRITISH COLUMBIA V6E 4T6 CA CANADA
CREST INTERNATIONAL NOMINEES LIMITED33 CANNON STREET LONDON EC4M 5SB GB UNITED KINGDOCURVATURE SECURITIES, LLC39 MAIN STREET CHATHAM NJ NEW JERSEY 07928 US
D.A. DAVIDSON & CO.8 3RD STREET NORTH GREAT FALLS MT MONTANA 59401 USDEPOSITO CENTRAL DE VALORES S.A., DEPOSITO DE VALORESAVENIDA APOQUINDO # 4001 FLOOR 12, C.P. 7550162, SANTIAGO CL CHILE
DESJARDINS SECURITIES INC.1253 McGill College 10TH FLOOR MONTREAL QUEBEC H3B 2Y5 CA CANADADEUTSCHE BANK AG NY/US CUSTODY1251 Avenue Of The Americas NEW YORK NY NEW YORK 10020
DEUTSCHE BANK SECURITIES INC.60 WALL STREET 9TH FLOOR NEW YORK NY NEW YORK 10005 USDRIVEWEALTH, LLC15 EXCHANGE PLACE 10TH FLOOR JERSEY CITY NEW JERSEY 07302
E*TRADE CLEARING LLCHARBORSIDE FINANCIAL CENTER 501 PLAZA 11 JERSEY CITY NJ NEW JERSEY 07311 USEDWARD D. JONES & CO., L.P.12555 MANCHESTER ROAD ST. LOUIS MO MISSOURI 63131-3729 US
EDWARD D. JONES & CO., L.P.201 PROGRESS PARKWAY MARYLAND HEIGHTS MO MISSOURI 63043 USFIDELITY CLEARING CANADA ULC/CDS**483 BAY ST. SOUTH TOWER TORONTO ON ONTARIO M5G2N7 CA CANADA
Broker NameBroker Address Broker Name
FIFTH THIRD BANK5001 KINGSLEY DRIVE MAIL DROP 1MOB28 CINCINNATI OH OHIO 45227 USFOLIO INVESTMENTS, INC.8180 GREENSBORO DRIVE 8TH FLOOR MCLEAN VA VIRGINIA 22102 US
FUTU CLEARING INC.12750 Merit Drive SUITE 475 DALLAS TX TEXAS 75251GMP SECURITIES L.P.145 KING STREET WEST, SUITE 300 11TH FLOOR TORONTO ON ONTARIO MJ5 1J8 CA CANADA
GOLDMAN, SACHS & CO. LLC222 SOUTH MAIN STREET Attn: Mandatory Corporate Actions SALT LAKE CITY UT UTAH 84101 USHAYWOOD SECURITIES INC./CDS**200 BURRARD ST WATERFRONT CENTRE SUITE 700 VANCOUVER BC BRITISH COLUMBIA V6C 3L6 CANADA
HILLTOP SECURITIES INC.1201 ELM ST. 35TH FLOOR DALLAS TX TEXAS 75270 USHRT FINANCIAL LLC150 GREENWICH STREET (ATTN: SETTLEMENT) FOUR WORLD TRADE CENTER 57TH FLOOR NEW YORK NY NEW YORK 10007 US
HSBC BANK USA, NA/HSBC CUSTODY & CLEARING SERVICES FOR STOCK LOAN452 FIFTH AVENUE ATTN: HBUS CCS SETTS NEW YORK NY NEW YORK 10018 USHSBC BANK USA, NATIONAL ASSOCIATION452 FIFTH AVENUE ATTN: HBUS CCS SETTS NEW YORK NEW YORK 10018 US
INTERACTIVE BROKERS LLC2 PICKWICK PLAZA 2ND FLOOR GREENWICH CT CONNECTICUT 06830 USJ.P. MORGAN CHASE BANK NA/FBO BLACKROCK CTF1111 POLARIS PARKWAY COLUMBUS OH OHIO 43240
J.P. MORGAN CLEARING CORP.FOUR CHASE METROTECH CENTER 3RD FLOOR BROOKLYN NY NEW YORK 11201 USJANNEY MONTGOMERY SCOTT LLC1717 ARCH STREET 17TH FLOOR PHILADELPHIA PA PENNSYLVANIA 19103 US
Broker NameBroker Address Broker Name
JEFFERIES LLC101 HUDSON STREET, 11th Floor NEW JERSEY NJ NEW JERSEY 07302 USJPMORGAN CHASE BANK, NATIONAL ASSOCIATIONFOUR CHASE METROTECH CENTER 3RD FLOOR BROOKLYN NY NEW YORK 11201 US
JPMORGAN CHASE BANK/EUROCLEAR BANKFOUR CHASE METROTECH CENTER 3RD FLOOR BROOKLYN NY NEW YORK 11245 USJPMORGAN CHASE BANK/IAFOUR CHASE METROTECH CENTER 3RD FLOOR BROOKLYN NY NEW YORK 11201 US
KEYBANK NATIONAL ASSOCIATION4900 TIEDEMAN RD BROOKLYN OH OHIO 44144 USLAURENTIAN BANK SECURITIES INC.1981 MCGILL COLLEGE AVE. SUITE 100 MONTREAL QUEBEC H3A 3K3 CA CANADA
LPL FINANCIAL LLC4707 EXECUTIVE DRIVE SAN DIEGO CA CALIFORNIA 92121 USMANUFACTURERS AND TRADERS TRUST COMPANYONE M&T PLAZA TRUST OPS 8TH FLOOR BUFFALO NY NEW YORK 14203 US
MANULIFE SECURITIES INCORPORATED1235 NORTH SERVICE ROAD WEST OAKVILLE ON ONTARIO L6M 2W2 CA CANADAMARSCO INVESTMENT CORPORATION101 EISENHOWER PARKWAY ROSELAND NJ NEW JERSEY 07068 US
MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED4804 Deer Lake Drive East FL9-803-04-04- 4th floor JACKSONVILLE FL FLORIDA 32246 USMIRAE ASSET SECURITIES (USA) INC./STOCK LOAN CONDUIT ACCOUNT810 SEVENTH AVE 37TH FLOOR NEW YORK NY NEW YORK 10019
MIRAE ASSET SECURITIES (USA), INC.810 SEVENTH AVE 37TH FLOOR NEW YORK NY NEW YORK 10019MITSUBISHI UFJ TRUST & BANKING CORPORATION, NEW YORK BRANCH280 PARK AVE 39TH FL-WEST BLDG NEW YORK NY NEW YORK 10017
Broker NameBroker Address Broker Name
Morgan Stanley1300 THAMES STREET THAMES STREET WHARF BALTIMORE MD MARYLAND 21231 USMORGAN STANLEY & CO. LLC1300 THAMES ST. BALTIMORE MD MARYLAND
MORGAN STANLEY SMITH BARNEY LLC1 NEW YORK PLAZA 39TH FLOOR NEW YORK NY NEW YORK 10004 USMURIEL SIEBERT & CO., INC.77 SUMMER STREET 3RD FLOOR BOSTON MA MASSACHUSETTS 02210 US
NATIONAL FINANCIAL SERVICES LLC499 WASHINGTON BOULEVARD 5TH FLOOR JERSEY CITY NJ NEW JERSEY 07310 USNBCN INC.1010 rue De La Gauchetière Mezzanine 100 MONTREAL QUEBEC H3B 5J2 CA CANADA
NOMURA INTERNATIONAL TRUST COMPANY309 WEST 49TH STREET 10TH FLOOR NEW YORK NY NEW YORK 10019 USODLUM BROWN LIMITED250 HOWE STREET SUITE 1100 VANCOUVER BC BRITISH COLUMBIA V6C 3R8 CA CANADA
OPPENHEIMER & CO. INC.85 BROAD STREET NEW YORK NY NEW YORK 10004 USPERSHING LLC1 PERSHING PLAZA JERSEY CITY NJ NEW JERSEY 07399 US
PHILLIP CAPITAL INC.141 W. JACKSON BLVD. SUITE 3050 CHICAGO IL ILLINOIS 60604 USPI FINANCIAL CORP.666 BURRARD ST SUITE 1900 VANCOUVER BC BRITISH COLUMBIA V6C 3N1 CA CANADA
PNC BANK, NATIONAL ASSOCIATION4100 W 150TH STREET ASSET MOVEMENT TEAM 3RD FL, LOCATOR B7- YB17-03-03 CLEVELAND OH OHIO 44135 USPRINCIPAL BANK711 HIGH STREET DES MOINES IA IOWA 50392
QUESTRADE INC./CDS**5650 YONGE ST., Suite 1700Raymond James & Associates, Inc.880 CARILLON PKWY ST. PETERSBURG
Broker NameBroker Address Broker Name
 TORONTO ON ONTARIO M2M 4G3 CA CANADA FL FLORIDA 33733-2749 US
RAYMOND JAMES LTD.925 WEST GEORGIA STREET SUITE 2200 VANCOUVER BC BRITISH COLUMBIA V6C 3L2 CA CANADARBC CAPITAL MARKETS, LLC60 SOUTH 6TH ST. MINNEAPOLIS MN MINNESOTA 55402 US
RBC DOMINION SECURITIES INC21 COMMERCE COURT SOUTH 2ND FLOOR TORONTO ON ONTARIO M5L 1A7 CANADARELIANCE TRUST COMPANY1100 ABERNATHY RD. 500 NORTHPARK SUITE 400 ATLANTA GA GEORGIA 30113 US
RELIANCE TRUST COMPANY4900 W. BROWN DEER RD MILWAUKEE WI WISCONSIN 53223 USROBERT W. BAIRD & CO. INCORPORATED777 E WISCONSIN AVE 9TH FLOOR MILWAUKEE WI WISCONSIN 53202 US
ROBINHOOD SECURITIES, LLC500 COLONIAL CENTER PARKWAY SUITE 100 LAKE MARY FL FLORIDA 32746 USSAFRA SECURITIES LLC546 5TH AVENUE NEW YORK NY NEW YORK 10036 US
SCOTIA CAPITAL (USA) INC.150 KING STREET W 5TH FLOOR TORONTO ON ONTARIO M5H 1J9 CA CANADASEI PRIVATE TRUST COMPANY1 FREEDOM VALLEY DRIVE OAKS PA PENNSYLVANIA 19456 US
SEI PRIVATE TRUST COMPANY1 FREEDOM VALLEY DRIVE OAKS PA PENNSYLVANIA 19456 USSG AMERICAS SECURITIES, LLC480 WASHINGTON BLVD. 20TH FLOOR JERSEY CITY NJ NEW JERSEY 07310 US
Broker NameBroker Address Broker Name
SSB – BLACKROCK INSTITUTIONAL TRUST50 California Street San Francisco CA CALIFORNIA 94163SSB – TRUST CUSTODY30 ADELAIDE ST EAST SUITE 800 TORONTO ON ONTARIO M5C 3G6 CA CANADA
SSB&T CO/CLIENT CUSTODY SERVICES1776 HERITAGE DRIVE NORTH QUINCY MA MASSACHUSETTS 02171STATE STREET BANK & TRUST CO16 WALL STREET 5TH FLOOR NEW YORK NY NEW YORK 10005 US
STATE STREET BANK & TRUST COMPANY / ISHARES EUROPE1776 HERITAGE DRIVE NORTH QUINCY MA MASSACHUSETTS 02171STATE STREET BANK & TRUST/STATE STREET TOTALETF1776 Heritage Drive NORTH QUINCY MA MASSACHUSETTS 02717
STATE STREET BANK AND TRUST COMPANY30 ADELAIDE ST EAST SUITE 800 TORONTO ON ONTARIO M5C 3G6 CA CANADASTIFEL, NICOLAUS & COMPANY, INCORPORATED501 N BROADWAY ST. LOUIS MO MISSOURI 63102 US
STONEX FINANCIAL INC.2 PERIMETER PARK SOUTH SUITE 100 W BIRMINGHAM AL ALABAMA 35243 USTD AMERITRADE CLEARING, INC.200 S 108TH AVE OMAHA NE NEBRASKA 68154 US
TD WATERHOUSE CANADA INC ATTN: MANDATORY CORPORATE ACTIONS77 BLOOR STREET WEST 3RD FLOOR TORONTO ON ONTARIO M5S 1M2 CA CANADATEXAS TREASURY SAFEKEEPING TRUST COMPANY208 E 10TH ST AUSTIN TX TEXAS 78701 US
THE BANK OF NEW YORK MELLON500 GRANT STREET 27TH FLOOR PITTSBURGH PA PENNSYLVANIA 15258 USTHE HUNTINGTON NATIONAL BANK7 EASTON OVAL EA4E62 COLUMBUS OH OHIO 43209 US
Broker NameBroker Address Broker Name
THE NORTHERN TRUST COMPANY333 South Wabash Ave, 32nd Floor Attn: Trade Securities Processing CHICAGO IL ILLINOIS 60603 USTRADESTATION SECURITIES, INC.120 RIVERSIDE PLAZA SUITE 1650 CHICAGO IL ILLINOIS 60606 US
U.S. BANCORP INVESTMENTS, INC.60 LIVINGSTON AVE EP-MN-WN1B ST. PAUL MN MINNESOTA 55107-1419 USU.S. BANK N.A./ETF1555 N RIVER CENTER DRIVE MILWAUKEE WI WISCONSIN 53212
U.S. BANK NATIONAL ASSOCIATION1555 NORTH RIVERCENTER DRIVE, SUITE 302 SUITE 302 MILWAUKEE WI WISCONSIN 53212 USUBS AG480 WASHINGTON BLVD. 12TH FLOOR JERSEY CITY NJ NEW JERSEY 07310 US
UBS FINANCIAL SERVICES INC.1000 HARBOR BOULEVARD WEEHAWKEN NJ NEW JERSEY 07086 USUBS SECURITIES LLC677 WASHINGTON BLVD STAMFORD CT CONNECTICUT 06901 US
UMB BANK, NATIONAL ASSOCIATION928 GRAND BLVD KANSAS CITY MO MISSOURI 64106 USVANGUARD MARKETING CORPORATION100 VANGUARD BLVD MALVERN PA PENNSYLVANIA 19355 US
VELOCITY CLEARING, LLC1301 Route 36 Suite 109 (Attn: Chris Felicetti) HAZLET NEW JERSEY 7730 USVELOX CLEARING LLC2400 E. KATELLA AVENUE SUITE 725A ANAHEIM CA CALIFORNIA 92806 US
VIRTU AMERICAS LLCONE LIBERTY PLAZA, 165 BROADWAY 5TH FLOOR NEW YORK NY NEW YORK 10006 USVISION FINANCIAL MARKETS LLC4 HIGH RIDGE PARK SUITE 100 STAMFORD CT CONNECTICUT 06905 US
WEDBUSH SECURITIES INC1000 WILSHIRE BLVD 8TH FLOORWEDBUSH SECURITIES INC.1000 WILSHIRE BLVD. LOS ANGELES
Broker NameBroker Address Broker Name
 LOS ANGELES CA CALIFORNIA 90017 US CA CALIFORNIA 90017 US
WELLS FARGO BANK, N.A./SIG733 MARQUETTE AVE 4TH FLOOR MAC N9306-04D MINNEAPOLIS MN MINNESOTA 55402 USWELLS FARGO CLEARING SERVICES LLC1 NORTH JEFFERSON MAIL CODE: H0006- 094 ST. LOUIS MO MISSOURI 63103 US
WELLS FARGO SECURITIES, LLC1525 WEST W T HARRIS BLVD CHARLOTTE NC NORTH CAROLINA 28262 USWILSON-DAVIS & CO., INC.236 SOUTH MAIN STREET SALT LAKE CITY UT UTAH 84101 US

About Scilex Holding Company

Scilex Holding Company, a majority-owned by Sorrento Therapeutics, Inc., is an innovative revenue- generating company focused on acquiring, developing, and commercializing non-opioid pain management products for the treatment of acute and chronic pain. Scilex is uncompromising in its focus to become the global pain management leader committed to social, environmental, economic, and ethical principles to responsibly develop pharmaceutical products to maximize quality of life. Results from the Phase III Pivotal Trial C.L.E.A.R Program for SEMDEXATM, its novel, non-opioid product for the treatment of lumbosacral radicular pain (sciatica), were announced in March 2022. Scilex has applied for breakthrough therapy designation and expects to seek priority review for SEMDEXATM for the treatment of sciatica. Scilex targets indications with high unmet needs and large market opportunities with non- opioid therapies for the treatment of patients with moderate to severe pain. Scilex launched its first commercial product in October 2018, in-licensed a commercial product in June 2022, and is developing its late-stage pipeline, which includes a pivotal Phase 3 candidate and one Phase 2 and one Phase 1 candidate. Its commercial product, ZTlido® (lidocaine topical system) 1.8%, or ZTlido®, is a prescription lidocaine topical product approved by the U.S. Food and Drug Administration for the relief of pain associated with postherpetic neuralgia, which is a form of post-shingles nerve pain. Scilex in- licensed the exclusive right to commercialize Gloperba® (colchicine USP) oral solution, an FDA- approved prophylactic treatment for painful gout flares in adults, in the U.S. Scilex is planning to commercialize Gloperba® in 2023 and is well-positioned to market and distribute the product. Scilex’s three product candidates are SP-102 (injectable dexamethasone sodium phosphate viscous gel product containing 10 mg dexamethasone), or SEMDEXA™, a Phase 3, novel, viscous gel formulation of a widely used corticosteroid for epidural injections to treat lumbosacral radicular pain, or sciatica, with FDA Fast Track status; SP-103 (lidocaine topical system) 5.4%, a Phase 2, triple-strength formulation of ZTlido®, for the treatment of low back pain, with FDA Fast Track status; and SP-104, 4.5 mg Delayed Burst Release Low Dose Naltrexone Hydrochloride (DBR-LDN) Capsule, for the treatment of chronic pain, fibromyalgia that has completed multiple Phase 1 trial programs and expected to initiate Phase 2 trials this year. For further information regarding the SP-102 Phase 3 efficacy trial, see NCT identifier NCT03372161 – Corticosteroid Lumbar Epidural Analgesia for Radiculopathy – Full Text View – ClinicalTrials.gov.

Scilex Holding Company is headquartered in Palo Alto, California, with operations in both Palo Alto and San Diego, California. For further information please visit www.scilexholding.com.

About Sorrento Therapeutics, Inc.

Sorrento is a clinical and commercial stage biopharmaceutical company developing new therapies to treat cancer, pain (non-opioid treatments), autoimmune disease and COVID-19. Sorrento’s multimodal, multipronged approach to fighting cancer is made possible by its extensive immuno-oncology platforms, including key assets such as Abivertinib, next-generation tyrosine kinase inhibitors (“TKIs”), fully human antibodies (“G-MAB™ library”), immuno-cellular therapies (“DAR-T™”), antibody-drug conjugates

(“ADCs”), and oncolytic virus (“Seprehvec™”). Sorrento is also developing potential antiviral therapies and vaccines against coronaviruses, including STI-1558, COVI-MSC™; and diagnostic test solutions, including COVIMARK™.

Sorrento’s commitment to life-enhancing therapies for patients is also demonstrated by our effort to advance a TRPV1 agonist, non-opioid pain management small molecule, resiniferatoxin (“RTX”), and SP-102 (10 mg, dexamethasone sodium phosphate viscous gel) (SEMDEXA™), a novel, viscous gel formulation of a widely used corticosteroid for epidural injections to treat lumbosacral radicular pain, or sciatica, and to commercialize ZTlido® (lidocaine topical system) 1.8% for the treatment of postherpetic neuralgia (PHN). RTX has been cleared for a Phase II trial for intractable pain associated with cancer and a Phase II trial in osteoarthritis patients. Positive final results from the Phase III Pivotal Trial C.L.E.A.R. Program for SEMDEXA™, its novel, non-opioid product for the treatment of lumbosacral radicular pain (sciatica), were announced in March 2022. ZTlido® was approved by the FDA on February 28, 2018.

For more information visit www.sorrentotherapeutics.com.

Contacts:

For Scilex Holding Company Jaisim Shah

Chief Executive Officer Scilex Holding Company 960 San Antonio Road Palo Alto, CA 94303 Office: (650) 516-4310

Email: jshah@scilexpharma.com

Website: www.sorrentotherapeutics.com and www.scilexholding.com

Investors and Media Contact:

Elizabeth Czerepak

Email: mediarelations@sorrentotherapeutics.com Website: www.sorrentotherapeutics.com

Sorrento® and the Sorrento logo are registered trademarks of Sorrento Therapeutics, Inc.

G-MAB™, DAR-T™, Seprehvec™, SOFUSA™, COVI-MSC™, COVIMARK™, Ovydso™ and FujoveeTM are trademarks of Sorrento Therapeutics, Inc.

SEMDEXA™ (SP-102) is a trademark owned by Semnur Pharmaceuticals, Inc., a wholly-owned subsidiary of Scilex Holding Company. A proprietary name review by the FDA is planned.

ZTlido® is a registered trademark owned by Scilex Pharmaceuticals Inc., a wholly-owned subsidiary of Scilex Holding Company.

Gloperba® is an exclusive, transferable license to use the trademark by Scilex Holding Company. All other trademarks are the property of their respective owners.

© 2023 Sorrento Therapeutics, Inc. All Rights Reserved.